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Connecting the Dots: A Review of Resting Connectivity MRI Studies in Attention Deficit/Hyperactivity Disorder, by Posner, Park, and Wang

01/03/2014 (Aprox)


Moreover, as often explained, psychopathology “is increasingly viewed from a circuit perspective in which a disorder stems not from circumscribed anomalies in discrete brain regions, but rather from impairments in distributed neural networks” (Posner, Park, and Wang 2014, 3). Yet, in the same way that the shift to biomarkers coexists with a desire for causality, the emphasis on neurocircuitry has in most cases barely altered the localizationist logic that drives the research.


Vidal, Fernando and Ortega, Francisco. Being Brains: Making the Cerebral Subject (Forms of Living)....

Jonathan E. Posner, MD, is a professor of the Department of Psychiatry at Columbia University.

Jonathan E. Posner, MD

Abstract

Psychopathology is increasingly viewed from a circuit perspective in which a disorder stems not from circumscribed anomalies in discrete brain regions, but rather from impairments in distributed neural networks. This focus on neural circuitry has rendered resting state functional connectivity MRI (rs-fcMRI) an increasingly important role in the elucidation of pathophysiology including attention-deficit/hyperactivity disorder (ADHD). Unlike many other MRI techniques that focus on the properties of discrete brain regions, rs-fcMRI measures the coherence of neural activity across anatomically disparate brain regions, examining the connectivity and organization of neural circuits. In this review, we explore the methods available to investigators using rs-fcMRI techniques, including a discussion of their relative merits and limitations. We then review findings from extant rs-fcMRI studies of ADHD focusing on neural circuits implicated in the disorder, especially the default mode network, cognitive control network, and cortico-striato-thalamo-cortical loops. We conclude by suggesting future directions that may help advance subsequent rs-fcMRI research in ADHD.

You can learn more about the article below:

Posner, Jonathan, Christine Park, and Zhishun Wang. 2014. “Connecting the Dots: A Review of Resting...

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Published in 13/02/2019

Updated in 19/02/2021

All events in the topic Chap. 3: Cerebralizing Distress:


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