Skip to content

Synthetization of Chlorpromazine

01/12/1951 (Aprox)


The discovery in the 1950s of the antipsychotic and antidepressant effect of certain synthetic compounds (chlorpromazine was the first) and the subsequent introduction of prescription psychotropic drugs gave rise to the claim that mental illness is caused by a “chemical imbalance” in the brain (Whitaker 2010).


Vidal, Fernando and Ortega, Francisco. Being Brains: Making the Cerebral Subject (Forms of Living)....

Structure of Chlorpromazine

Image source

History of Chlorpromazine

Chlorpromazine was synthesized on December 11, 1951 by Paul Charpentier, in the laboratories of Rhône-Poulenc, a French pharmaceutical company, and released for clinical investigation in May 1952 as a possible potentiator of general anesthesia (Charpentier et al. 1952).

The potential use of CPZ in psychiatry was first recognized by Henri Laborit (1952), a surgeon and physiologist in the French army, in the course of his research with artificial hibernation in the prevention of surgical shock. In collaboration with Huguenard and Alluaume, he employed the drug as an adjunct to surgical anesthetics (“anesthetic cocktail,” “lytic cocktail”) because of its body temperature lowering effect. [...]

Since cooling with water had been used in France for controlling agitation (Burger 1976), Laborit was able to persuade Hamon, Paraire and Velluz at the neuropsychiatric service of Val de Grâce, the military hospital in Paris, to try CPZ in the treatment of one of their patients (Caldwell 1970). Jacques Lh., a 24-year-old severely agitated psychotic (manic) male was the first psychiatric patient to receive CPZ; he was administered 50 mg of the drug, intravenously, at 10 am, on January 19, 1952. The calming effect of CPZ was immediate but since it lasted only a few hours several treatments were required before the patient’s agitation was controlled.

Read the complete history on the article below:

Fifty years chlorpromazine: a historical perspective, by Thomas A. Ban

The Evidence for Chlorpromazine

0 comments

Comment

No comments avaliable.

Author

Info

Published in 29/01/2019

Updated in 19/02/2021

All events in the topic Chap. 3: Cerebralizing Distress:


01/09/2007 (Aprox)Can Neuroscience be integrated into the DSM-V?, by Steven HymanCan Neuroscience be integrated into the DSM-V?, by Steven Hyman
02/01/2011 (Aprox)The Pharma-Psych NexusThe Pharma-Psych Nexus
01/01/1997 (Aprox)01/01/2013 (Aprox)Books by David HealyBooks by David Healy
01/12/1951 (Aprox)Synthetization of ChlorpromazineSynthetization of Chlorpromazine
12/08/2014Is Evidence-based Psychiatry Ethical?, by Mona Gupta
03/01/2007 (Aprox)Global Mental Health Movement (GMH)
01/01/2008 (Aprox)Mental Health Gap Action Programme (mhGAP)
01/01/2002 (Aprox)01/01/2013 (Aprox)Globalization of PsychiatryGlobalization of Psychiatry
01/01/2001 (Aprox)World Health ReportWorld Health Report
03/01/2005 (Aprox)The bio-bio-bio model of madness, by John ReadThe bio-bio-bio model of madness, by John Read
01/03/2012 (Aprox)The Epigenetics Revolution, by Nessa CareyThe Epigenetics Revolution, by Nessa Carey
01/01/2010 (Aprox)Major Depressive Disorder: 2nd leading cause of disability worldwideMajor Depressive Disorder: 2nd leading cause of disability worldwide
01/01/2011 (Aprox)The pharmaceutical industry's turn: from medication to geneticsThe pharmaceutical industry's turn: from medication to genetics
10/07/2014Most recent edition of the Handbook of DepressionMost recent edition of the Handbook of Depression
01/07/2000 (Aprox)Nosologomania: A Disorder of Psychiatry, by Herman van PraagNosologomania: A Disorder of Psychiatry, by Herman van Praag
15/09/2014Melancholia: The Western Malady, by Matthew BellMelancholia: The Western Malady, by Matthew Bell
18/10/2005Can Brain Scans See Depression?, by Benedict CareyCan Brain Scans See Depression?, by Benedict Carey
03/01/2008 (Aprox)Biological Vulnerability of Depression, by Nantel-Vivier and PihlBiological Vulnerability of Depression, by Nantel-Vivier and Pihl
02/01/2002 (Aprox)Functional Neuroimaging of Depression, by Erk, Walter and SpitzerFunctional Neuroimaging of Depression, by Erk, Walter and Spitzer
01/02/2002 (Aprox)Depression: Perspectives from Affective Neuroscience, by Davidson et al.Depression: Perspectives from Affective Neuroscience, by Davidson et al.
02/01/2014 (Aprox)The Neurobiology of Meditation and Mindfulness, by Tobias EschThe Neurobiology of Meditation and Mindfulness, by Tobias Esch
20/09/2013Concentrating on Kindness, an article on Science MagConcentrating on Kindness, an article on Science Mag
02/01/2009 (Aprox)Lack of evidence of causality in depressionLack of evidence of causality in depression
02/01/2013 (Aprox)Classification of Depressive Disorders, by Philip J. CowenClassification of Depressive Disorders, by Philip J. Cowen
03/01/2013 (Aprox)The search for treatment-specific biomarkersThe search for treatment-specific biomarkers
04/01/2013 (Aprox)Hopes for diagnostic based on identified biomarkers
16/01/2001A Default Mode of Brain Function, by Raichle et al.A Default Mode of Brain Function, by Raichle et al.
03/01/1998 (Aprox)Thoughts on Finding Myself Differently Brained, by Jane MeyerdingThoughts on Finding Myself Differently Brained, by Jane Meyerding
02/01/1999 (Aprox)Why Can’t You Be Normal for Once in Your Life? by Judy SingerWhy Can’t You Be Normal for Once in Your Life? by Judy Singer
01/01/1998 (Aprox)NeurodiversityNeurodiversity
01/01/1940 (Aprox)01/01/1975 (Aprox)Influence of psychoanalytic explanationsInfluence of psychoanalytic explanations
01/01/1960 (Aprox)The Divided Self, by Ronald LaingThe Divided Self, by Ronald Laing
01/01/1967 (Aprox)Psychiatry and Anti-Psychiatry, by David CooperPsychiatry and Anti-Psychiatry, by David Cooper
01/03/1973 (Aprox)Mental Patients' UnionMental Patients' Union
01/01/1962 (Aprox)National Autistic SocietyNational Autistic Society
01/01/1965 (Aprox)Autism Society of AmericaAutism Society of America
01/01/1990 (Aprox)The rise of Internet
01/01/1992 (Aprox)01/01/1996 (Aprox)Autism Network InternationalAutism Network International
01/01/1994 (Aprox)National Alliance for Autism ResearchNational Alliance for Autism Research
03/01/1995 (Aprox)Cure Autism Now FoundationCure Autism Now Foundation
18/11/2004Petition to the United Nations
02/01/1995 (Aprox)Thinking in Pictures, by Temple GrandinThinking in Pictures, by Temple Grandin
01/01/2005 (Aprox)Acceptance Versus Cure, by Sue RubinAcceptance Versus Cure, by Sue Rubin
18/07/2005First Autistic Pride DayFirst Autistic Pride Day
02/01/2005 (Aprox)A Mother's Perspective, by Kit Weintraub
01/01/1999 (Aprox)Why I Dislike 'Person First' Language, by Jim Sinclair
01/01/1995 (Aprox)The Looping Effects of Human Kinds, by Ian HackingThe Looping Effects of Human Kinds, by Ian Hacking
02/01/2006 (Aprox)On Our Own Terms: Emerging Autistic Culture, by Martijn DekkerOn Our Own Terms: Emerging Autistic Culture, by Martijn Dekker
01/01/1997 (Aprox)Autism Genetic Resource ExchangeAutism Genetic Resource Exchange
01/01/2006 (Aprox)Voices From The Spectrum, by Ariel and NaseefVoices From The Spectrum, by Ariel and Naseef
02/01/1998 (Aprox)Institute for the Study of the Neurologically TypicalInstitute for the Study of the Neurologically Typical
25/08/2010AspergiaAspergia
01/01/2013 (Aprox)The Book of Woe, by Gary GreenbergThe Book of Woe, by Gary Greenberg
10/03/2007Light and Dark: Correcting the Balance, by Judy SingerLight and Dark: Correcting the Balance, by Judy Singer