The search for treatment-specific biomarkers

03/01/2013 (Circa)View on timeline


Neuroimaging depression research has kept looking for treatment-specific biomarkers capable of predicting an individual’s improvement in response to a particular treatment and nonresponse to an alternative treatment. For example, it has been suggested that neural response to emotional stimuli in visual cortical areas might be a useful biomarker for identifying patients who will respond favorably to scopolamine (Furey et al. 2013).


Similarly, in 2012 another study confirmed earlier suggestions that decreased reactivity to negative words in the subgenual anterior cingulate cortex (sgACC) predicts outcome in cognitive therapy for depression (Siegle et al. 2012; cf. Greicius et al. 2007). And research published in 2013 found that insula hypometabolism is associated with good results with cognitive behavioral therapy and poor response to escitalopram (a selective serotonin reuptake inhibitor), and insula hypermetabolism, with remission to escitalopram and poor response to the same kind of therapy (McGrath et al. 2013).

Vidal, Fernando and Ortega, Francisco. Being Brains: Making the Cerebral Subject (Forms of Living)....

NIMH's Dr. Maura Furey on scopolamine research
Image taken from the article by Furey et al. (2013), showing some of its results. The link to the ar...

Find all the articles in the order they were mentioned by Vidal and Ortega:

Furey, Maura L., et al. 2013. “Potential of Pretreatment Neural Activity in the Visual Cortex During...

Siegle, Greg J., Wesley K. Thompson, Amanda Collier, et al. 2012. “Toward Clinically Useful Neuroima...

Greicius, Michael D., et al. 2007. “Resting-State Functional Connectivity in Major Depression: Abnor...

McGrath, Callie L., et al. 2013. “Toward a Neuroimaging Treatment Selection Biomarker for Major Depr...

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Published in 7/02/2019

Updated in 19/02/2021

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