Neuroimaging and Depression: Current Status and Unresolved Issues, by Gotlib and Hamilton

01/04/2008 (Circa)


While the scientific literature invariably underlines progress in knowledge of the brain structures said to “subserve” or be involved in depression, it also acknowledges persistent ignorance about causality and localization. In 2008, for example, an article in Current Directions in Psychological Science reviewed the status and unresolved issues in neuroimaging and depression.


It summarized neurocorrelational research, assessing the role of several brain structures in major depression, and concluded that heightened activity in the limbic structures engaged in emotional experience and expression dampens activation in the dorsal cortical structures involved in affect regulation. The article devoted different sections to distinct structures or systems (the amygdala, the subgenual anterior cingulate cortex, and the dorsolateral prefrontal cortex) and pointed out that identifying “the patterns of functional connectivity that characterize the depressive neural network” was still a challenge for future work (Gotlib and Hamilton 2008, 161).

As in earlier literature, the findings discussed in the 2008 Current Directions article “underscore the fact that ‘depression’ refers to a heterogeneous group of disorders that are not carved at their neurobiological joints in DSM-IV”; hence the desire to define depression subtypes and symptom profiles “that are related systematically to neural functional and structural abnormalities” (162). 

Vidal, Fernando and Ortega, Francisco. Being Brains: Making the Cerebral Subject (Forms of Living)....

Ian H. Gotlib is a psychologist at Stanford University. You can find more information about him else...
The source of the image above is also a very interesting 2018 interview with Dr. Gotlib. Read on:

Separation from parents removes children’s most important protection and generates a new trauma, Sta...

Ian H. Gotlib's co-author, Paul J. Hamilton, is a post-doctoral fellow at Stanford University. Find him at the University website: 

Paul Hamilton, PhD

To read the full article cited by Vidal and Ortega, click below:Gotlib, Ian, and Paul J. Hamilton. 2008. “Neuroimaging and Depression: Current Status and Unresolved...

0 comments

Comment
No comments avaliable.

Author

Info

Published in 6/02/2019

Updated in 19/02/2021

All events in the topic Chap. 3: Cerebralizing Distress:


01/09/2007 (Circa)Can Neuroscience be integrated into the DSM-V?, by Steven HymanCan Neuroscience be integrated into the DSM-V?, by Steven Hyman
02/01/2011 (Circa)The Pharma-Psych NexusThe Pharma-Psych Nexus
01/01/1997 (Circa)01/01/2013 (Circa)Books by David HealyBooks by David Healy
01/12/1951 (Circa)Synthetization of ChlorpromazineSynthetization of Chlorpromazine
12/08/2014Is Evidence-based Psychiatry Ethical?, by Mona Gupta
03/01/2007 (Circa)Global Mental Health Movement (GMH)
01/01/2008 (Circa)Mental Health Gap Action Programme (mhGAP)
01/01/2002 (Circa)01/01/2013 (Circa)Globalization of PsychiatryGlobalization of Psychiatry
01/01/2001 (Circa)World Health ReportWorld Health Report
03/01/2005 (Circa)The bio-bio-bio model of madness, by John ReadThe bio-bio-bio model of madness, by John Read
01/03/2012 (Circa)The Epigenetics Revolution, by Nessa CareyThe Epigenetics Revolution, by Nessa Carey
01/01/2010 (Circa)Major Depressive Disorder: 2nd leading cause of disability worldwideMajor Depressive Disorder: 2nd leading cause of disability worldwide
01/01/2011 (Circa)The pharmaceutical industry's turn: from medication to geneticsThe pharmaceutical industry's turn: from medication to genetics
10/07/2014Most recent edition of the Handbook of DepressionMost recent edition of the Handbook of Depression
01/07/2000 (Circa)Nosologomania: A Disorder of Psychiatry, by Herman van PraagNosologomania: A Disorder of Psychiatry, by Herman van Praag
15/09/2014Melancholia: The Western Malady, by Matthew BellMelancholia: The Western Malady, by Matthew Bell
18/10/2005Can Brain Scans See Depression?, by Benedict CareyCan Brain Scans See Depression?, by Benedict Carey
03/01/2008 (Circa)Biological Vulnerability of Depression, by Nantel-Vivier and PihlBiological Vulnerability of Depression, by Nantel-Vivier and Pihl
02/01/2002 (Circa)Functional Neuroimaging of Depression, by Erk, Walter and SpitzerFunctional Neuroimaging of Depression, by Erk, Walter and Spitzer
01/02/2002 (Circa)Depression: Perspectives from Affective Neuroscience, by Davidson et al.Depression: Perspectives from Affective Neuroscience, by Davidson et al.
02/01/2014 (Circa)The Neurobiology of Meditation and Mindfulness, by Tobias EschThe Neurobiology of Meditation and Mindfulness, by Tobias Esch
20/09/2013Concentrating on Kindness, an article on Science MagConcentrating on Kindness, an article on Science Mag
02/01/2009 (Circa)Lack of evidence of causality in depressionLack of evidence of causality in depression
02/01/2013 (Circa)Classification of Depressive Disorders, by Philip J. CowenClassification of Depressive Disorders, by Philip J. Cowen
03/01/2013 (Circa)The search for treatment-specific biomarkersThe search for treatment-specific biomarkers
04/01/2013 (Circa)Hopes for diagnostic based on identified biomarkers
16/01/2001A Default Mode of Brain Function, by Raichle et al.A Default Mode of Brain Function, by Raichle et al.
03/01/1998 (Circa)Thoughts on Finding Myself Differently Brained, by Jane MeyerdingThoughts on Finding Myself Differently Brained, by Jane Meyerding
02/01/1999 (Circa)Why Can’t You Be Normal for Once in Your Life? by Judy SingerWhy Can’t You Be Normal for Once in Your Life? by Judy Singer
01/01/1998 (Circa)NeurodiversityNeurodiversity
01/01/1940 (Circa)01/01/1975 (Circa)Influence of psychoanalytic explanationsInfluence of psychoanalytic explanations
01/01/1960 (Circa)The Divided Self, by Ronald LaingThe Divided Self, by Ronald Laing
01/01/1967 (Circa)Psychiatry and Anti-Psychiatry, by David CooperPsychiatry and Anti-Psychiatry, by David Cooper
01/03/1973 (Circa)Mental Patients' UnionMental Patients' Union
01/01/1962 (Circa)National Autistic SocietyNational Autistic Society
01/01/1965 (Circa)Autism Society of AmericaAutism Society of America
01/01/1990 (Circa)The rise of Internet
01/01/1992 (Circa)01/01/1996 (Circa)Autism Network InternationalAutism Network International
01/01/1994 (Circa)National Alliance for Autism ResearchNational Alliance for Autism Research
03/01/1995 (Circa)Cure Autism Now FoundationCure Autism Now Foundation
18/11/2004Petition to the United Nations
02/01/1995 (Circa)Thinking in Pictures, by Temple GrandinThinking in Pictures, by Temple Grandin
01/01/2005 (Circa)Acceptance Versus Cure, by Sue RubinAcceptance Versus Cure, by Sue Rubin
18/07/2005First Autistic Pride DayFirst Autistic Pride Day
02/01/2005 (Circa)A Mother's Perspective, by Kit Weintraub
01/01/1999 (Circa)Why I Dislike 'Person First' Language, by Jim Sinclair
01/01/1995 (Circa)The Looping Effects of Human Kinds, by Ian HackingThe Looping Effects of Human Kinds, by Ian Hacking
02/01/2006 (Circa)On Our Own Terms: Emerging Autistic Culture, by Martijn DekkerOn Our Own Terms: Emerging Autistic Culture, by Martijn Dekker
01/01/1997 (Circa)Autism Genetic Resource ExchangeAutism Genetic Resource Exchange
01/01/2006 (Circa)Voices From The Spectrum, by Ariel and NaseefVoices From The Spectrum, by Ariel and Naseef
02/01/1998 (Circa)Institute for the Study of the Neurologically TypicalInstitute for the Study of the Neurologically Typical
25/08/2010AspergiaAspergia
01/01/2013 (Circa)The Book of Woe, by Gary GreenbergThe Book of Woe, by Gary Greenberg
10/03/2007Light and Dark: Correcting the Balance, by Judy SingerLight and Dark: Correcting the Balance, by Judy Singer