Skip to content

Bayer invents aspirin

01/01/1899

Spirea, or meadowsweet, is the German namesake of Spirsäure (salicylic acid), and ultimately aspirin...

The history of aspirin (IUPAC name acetylsalicylic acid ) begins with its synthesis and manufacture in 1899. Before that, salicylic acid had been used medicinally since antiquity. Medicines made from willow and other salicylate-rich plants appear in clay tablets from ancient Sumer as well as the Ebers Papyrus from ancient Egypt. Hippocrates referred to their use of salicylic tea to reduce fevers around 400 BC, and were part of the pharmacopoeia of Western medicine in classical antiquity and the Middle Ages. Willow bark extract became recognized for its specific effects on fever, pain and inflammation in the mid-eighteenth century. By the nineteenth century pharmacists were experimenting with and prescribing a variety of chemicals related to salicin, the active component of willow extract.

In 1853, chemist Charles Frédéric Gerhardt treated acetyl chloride with sodium salicylate to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it. By 1899, Bayer had dubbed this drug Aspirin and was selling it around the world. The word Aspirin was Bayer's brand name, rather than the generic name of the drug; however, Bayer's rights to the trademark were lost or sold in many countries. Aspirin's popularity grew over the first half of the twentieth century leading to fierce competition with the proliferation of aspirin brands and products.

Aspirin's popularity declined after the development of acetaminophen/paracetamol in 1956 and ibuprofen in 1962. In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects, while clinical trials and other studies from the 1960s to the 1980s established aspirin's efficacy as an anti-clotting agent that reduces the risk of clotting diseases. Aspirin sales revived considerably in the last decades of the twentieth century, and remain strong in the twenty-first with widespread use as a preventive treatment for heart attacks and strokes.

0 comments

Comment

No comments avaliable.

Author

Info

Published in 3/04/2019

Updated in 19/02/2021

All events in the topic International Chronology:


01/07/1588Defeat of the Invincible Armada by the EnglishDefeat of the Invincible Armada by the English
01/01/1593Shakespeare writes Richard IIIShakespeare writes Richard III
01/01/1610Galileo invents the telescopeGalileo invents the telescope
01/03/1661Start of the reign of Louis XIVStart of the reign of Louis XIV
01/01/1687Denis Papin constructs the first steam engineDenis Papin constructs the first steam engine
17/05/175615/02/1763Seven Years’ WarSeven Years’ War
05/05/1789Outbreak of the French RevolutionOutbreak of the French Revolution
21/10/1805Battles of Trafalgar and AusterlitzBattles of Trafalgar and Austerlitz
21/02/1821Greece achieves independenceGreece achieves independence
20/06/1837Victoria is crowned Queen of EnglandVictoria is crowned Queen of England
24/11/1859Darwin - On the Origin of SpeciesDarwin - On the Origin of Species
01/12/1865Abolition of slavery in the USAAbolition of slavery in the USA
01/01/1884Construction of the first skyscraper in ChicagoConstruction of the first skyscraper in Chicago
01/01/1905Einstein - Theory of RelativityEinstein - Theory of Relativity
28/07/191411/11/1918First World WarFirst World War
01/01/1929Black Thursday on Wall StreetBlack Thursday on Wall Street
17/07/1936Start of the Spanish Civil WarStart of the Spanish Civil War
01/09/193902/09/1945Second World WarSecond World War
25/03/1957Signing of the Treaty of Rome - creation of the EECSigning of the Treaty of Rome - creation of the EEC
08/03/1965The USA intervenes in VietnamThe USA intervenes in Vietnam
09/11/1989Fall of the Berlin WallFall of the Berlin Wall
02/08/1990Outbreak of the Gulf WarOutbreak of the Gulf War
11/09/20012001 11 September2001 11 September
01/01/200731/12/2008Economic crisisEconomic crisis
01/01/1605Cervantes writes Don QuixoteCervantes writes Don Quixote
25/04/1719Daniel Defoe writes Robinson CrusoeDaniel Defoe writes Robinson Crusoe
09/07/1816Argentina achieves independenceArgentina achieves independence
05/05/1821Death of Napoleon BonaparteDeath of Napoleon Bonaparte
14/09/1822Champollion deciphers hieroglyphicsChampollion deciphers hieroglyphics
01/07/1844Alexandre Dumas publishes The Three MusketeersAlexandre Dumas publishes The Three Musketeers
01/02/1848Marx and Engels publish The Communist ManifestoMarx and Engels publish The Communist Manifesto
12/04/1861Outbreak of the American Civil WarOutbreak of the American Civil War
01/01/1865Tolstoy begins publication of War and PeaceTolstoy begins publication of War and Peace
24/12/1871Verdi's opera Aida is staged in CairoVerdi's opera Aida is staged in Cairo
07/03/1876Bell invents the telephoneBell invents the telephone
26/07/1882Wagner writes ParsifalWagner writes Parsifal
01/01/1885Karl Benz invents the first petrol-powered vehicleKarl Benz invents the first petrol-powered vehicle
13/02/1895Lumiére Brothers – 1st cinema projectionLumiére Brothers – 1st cinema projection
01/01/1899Bayer invents aspirinBayer invents aspirin
01/01/1912Proclamation of the Republic of ChinaProclamation of the Republic of China
14/04/1912Sinking of the TitanicSinking of the Titanic
08/03/1917Russian RevolutionRussian Revolution
01/01/1920Women granted the right to vote in the USAWomen granted the right to vote in the USA
01/01/1921Hitler becomes the leader of the Nazi PartyHitler becomes the leader of the Nazi Party
01/01/1923First broadcasting of images by televisionFirst broadcasting of images by television
27/07/1926Chang-Kai-Check reunifies ChinaChang-Kai-Check reunifies China
01/10/1927The start of sound filmThe start of sound film
18/11/1928Walt Disney creates Mickey MouseWalt Disney creates Mickey Mouse
01/01/1929Soviet Union – Stalin becomes undisputed leaderSoviet Union – Stalin becomes undisputed leader
01/08/1934Hitler becomes leader of German ReichHitler becomes leader of German Reich
01/01/1933Creation of the electronic microscopeCreation of the electronic microscope
15/02/1946First computer – ENIACFirst computer – ENIAC
01/10/1949Establishment of the People’s Republic of ChinaEstablishment of the People’s Republic of China
05/03/1953Death of StalinDeath of Stalin
13/08/1961Construction of the Berlin WallConstruction of the Berlin Wall
22/11/1963Assassination of President Kennedy in DallasAssassination of President Kennedy in Dallas
02/12/1805Battle of AusterlitzBattle of Austerlitz